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+--- Thread: Reversing aging might be possible (/showthread.php?tid=232073)
Re: Reversing aging might be possible - Yoyodyne ArtWorks - 09-09-2019
Mother Nature is trying to rid this planet of humans like a dog shaking off fleas. Let us not interfere with her good works.
miley-gen013:
Re: Reversing aging might be possible - freeradical - 09-09-2019
Yoyodyne ArtWorks wrote:
Mother Nature is trying to rid this planet of humans like a dog shaking off fleas. Let us not interfere with her good works.
:facepalm:
Re: Reversing aging might be possible - pRICE cUBE - 09-09-2019
Sooooooo.....isn't this how we end up with Zombies?
Re: Reversing aging might be possible - sekker - 09-09-2019
Newsweek did not even followup.
The Nature citation is a news article.
https://www.nature.com/articles/d41586-019-02638-w
The main paper can be accessed here:
https://www.gwern.net/docs/longevity/2019-fahy.pdf
None of the links in the Nature article seemed to work for me, so I thought I'd post.
This paper is quite preliminary in my opinion - including the idea that there is an 'epigenetic clock' is controversial.
Re: Reversing aging might be possible - NewtonMP2100 - 09-09-2019
....can you reverse Age of Innocence......???
Re: Reversing aging might be possible - Sarcany - 09-09-2019
From what I've read, the idea behind using methyl as a proxy for aging is that it accumulates over time and supposedly interferes with gene-expression and transcription. Whether it is a reliable indicator of age or infirmity is still up for debate.
I think it's similar to the shortening telomeres thing. Seemed to be a good way to estimate a subject's age, but clones end up with shorter telomeres than otherwise and often live normal-length lives, so it's more complicated than just the length of telomeres.
Correlation does not equal causation and all that...
Seems that there are lots of other factors: Accumulating DNA damage, fewer stem cells, viral infection (seems that common viruses have surprising influences on brain-function over time)... And general wear-and-tear.
Any geneticists in the forum who care to comment?
Re: Reversing aging might be possible - pdq - 09-09-2019
I don’t know about reversing aging, but I think drug (or gene) therapies slowing aging (already being done in experimental animals) may not be as many as 30 years away.
Re: Reversing aging might be possible - NewtonMP2100 - 09-09-2019
....so we can 'Benjamin Button'.....this sucker....???
Re: Reversing aging might be possible - Lew Zealand - 09-09-2019
No controls.
No researcher blinding.
Uses a proxy for actual effects.
This is the thinnest of preliminary data but at least it suggests obvious experiments to generate actual data.
Re: Reversing aging might be possible - NewtonMP2100 - 09-09-2019
....if I could turn back time.....if I could find....a way.....