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It makes doing things like clicking very difficult. Luckily I can tab through links on most webpages and type, but I don't think I will be able to actually hit the submit button to post this... yeah ok it will work.
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"The average lifespan of a wild mouse is typically one to two years, while mice kept as pets usually live about three years and have survived up to six years ..."
How old is your mouse?
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It's actually a Wacom Intuos2 tablet. The light comes on so the USB isn't totally dead, but I can't control the cursor at all. This happened just after installing the latest 10.5 and then migrating my old user account so I am trying to uninstall the old driver and get the latest one but it's hard to execute the uninstall without a working mouse!
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Have you recently added USB devices or swapped devices on your USB ports?
Those things have pretty steep power requirements and are best connected via powered hub or else they'll display symptoms much as you're describing.
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I have it plugged directly into the G5 so it should not be a power issue. The device is also showing up in the System Profiler.
So what I did was to get a temporary regular USB mouse, uninstall the Wacom tablet preference pane and driver, (using their uninstall utility), then repair permissions, restart, install the latest driver and now it works again. These steps were outlined on one of their support pages.
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Run Cocktail or the like. Several times Cocktail has solved even what seemed to be hardware problems for me.