08-02-2021, 12:36 AM
sekker wrote:
[quote=PeterB]
[quote=sekker]
[quote=PeterB]
[quote=Filliam H. Muffman]
I would consider a daily nasal spray to reduce susceptibility but it would need to either be shelf stable and available everywhere, or an auto-ship option.
The evidence that this virus is mutating so fast is disturbing, and still waiting for China to publish genetic profiles of the Wuhan 2015 Gain of Function research to prove it isn't related (like that is ever gonna happen).
I don't see why the nasal spray couldn't be both shelf-stable AND available everywhere. It's a lipopeptide, which I would guess should be pretty stable in formulation, and hopefully not too hard to mass-produce: https://www.nytimes.com/2020/11/05/healt...spray.html
There is a nasal spray-based next generation vaccine now in clinical trials. They just designed the version against the Delta variant. This could be the next step. But it will still be months before we know it works and is generally safe. Still, scientists are still 'sciencing' and trying to get new solutions - even if the politics are a challenge.
To which one are you referring? There are actually now a few nasal sprays in development; the one I linked to from the NYT is a lipoprotein, already tested on ferrets, but there are others in development (and one which is OTC and according to a publication, interferes with corona infection, though I'm not sure I believe their data).
https://www.postbulletin.com/newsmd/coro...cal-trials
Actual vaccine, nasal delivery. Very cool tech.
Interesting; but I thought the problem with adenoviral nasal-based vaccines is that (ironically) the body doesn't respond well to the adenovirus as a vector when it's applied intranasally rather than bloodstream injected? (That is, the body eliminates it right away...) And what about adjuvant?
I still like the idea of using a lipoprotein. Less complicated and probably easier to mass-produce.