08-31-2022, 03:41 PM
Tiangou wrote:
Based on testing on 10 mice.
Notoriously unreliable.
Mouse strains evolve and change, even when you try to hold their genome stable. Add in the fact that people are not mice, as the immune system is somewhat different (but close enough, maybe), and the fact that people are … odd … when it comes to variability from one person to the next, and the job becomes that much more difficult. And I’m meaning “odd” in that the more we study the immune system, the more we realize that genetic variability is huge in humans. Translation between the two species can be hard to do. There is enough similarities to make it worthwhile to do the work, but there is a reason that human trials are necessary.
Immortal cell lines do the same.