Installed Leopard . . . iTunes 7.5 not playing.

[WHiiP]

Thanks for the prompt response. In checking the Audio MIDI Setup, I am set up correctly, although the Audio Output window shows external speakers as grayed out. This is an iMac G4/ with the Harmon Kardon speaker and the iSub. I have double checked the Sound Preferences and they are set properly, but still no sound from the alerts or the volume adjustment.

Thanks again, any other options?