Please advise...it's been SO long

[prymsnap]

mikebw wrote:
Migration assistant is great, but if you feel like you have some extra baggage now might is the time to start clean.

I have a lot of old baggage and lingering problems that I never successfully resolved. So here's what I'd love to do: start absolutely fresh EXCEPT for my system settings. Is that possible? And on the other hand, if it is possible, is it wise in terms of a strategy?